hello.
in my experience in overnight-traveling in peru was very good. it was save and smooth traveling. if you spend a bit more money for companies like cruz del sur. you drive in very comftable bus (wifi, video-entertainment, blankets).
The whole journey takes you about 22 hours.
wie did the reverse way from cusco to arrequipa. and from there to lima. i liked arrequipa quite much. it's a wonderful city submontane to the misti. you can do rafting and enjoy the beautiful inner city. colca canyon is near.
The expected time would be:
- * Lima -> Arrequipa: 15 Hours
*Arrequipa -> Cusco: 10 hours
you can look for different connections directly at Cruz del Sur. there you can see also the estimated journey-times. the other companies have equal journey times.
hope i helped.
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